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Genetic Variants

Variant Gene Category Result
rs1001179 CAT Catalase promoter variant affecting hydrogen peroxide clearance and antioxidants defense capacity CAT Neuroinflammation & Oxidative Stress —
rs1006737 CACNA1C L-type calcium channel gene variant affecting mood regulation, emotional processing, and psychiatric disorder risk CACNA1C Mood & Depression —
rs10462020 PER3 Missense variant in circadian clock gene PER3 associated with morning chronotype preference and earlier diurnal timing PER3 Sleep & Circadian Rhythm —
rs1045642 ABCB1 Synonymous variant in P-glycoprotein affecting drug efflux pump expression and hundreds of substrate drugs ABCB1 Psychiatric Pharmacogenomics —
rs10830963 MTNR1B Melatonin receptor variant that extends nighttime melatonin signaling in pancreatic beta cells, impairing glucose-stimulated insulin secretion — especially when meals are eaten late MTNR1B Sleep & Circadian Rhythm —
rs11206244 DIO1 Common variant in the 3' UTR of the DIO1 gene affecting thyroid hormone metabolism and T3/T4 ratio DIO1 Neuroendocrine & Hormonal Mood —
rs1050450 GPX1 Selenium-dependent antioxidant enzyme that neutralizes hydrogen peroxide; the Leu variant reduces enzyme activity and responsiveness to selenium GPX1 Neuroinflammation & Oxidative Stress —
rs1050891 HNMT Histamine breakdown in blood and tissues - uses methyl groups from SAM HNMT Neurotransmitter Metabolism —
rs1065852 CYP2D6 Decreased function CYP2D6 variant common in Asian populations CYP2D6 Psychiatric Pharmacogenomics —
rs1360780 FKBP5 Co-chaperone of the glucocorticoid receptor that regulates cortisol feedback — the T allele impairs stress recovery and, combined with early adversity, strongly increases risk of PTSD and depression FKBP5 Anxiety & Stress Response —
rs1051266 SLC19A1 Folate transporter — how well folate gets into your cells SLC19A1 Methylation & Brain Nutrients —
rs1800629 TNF Promoter variant increasing TNF-alpha production approximately 2-fold, associated with autoimmune diseases and anti-TNF drug response TNF Anxiety & Stress Response, Neuroinflammation & Oxidative Stress —
rs1205 CRP 3' UTR variant that modulates baseline C-reactive protein levels and inflammatory status CRP Neuroinflammation & Oxidative Stress —
rs11605924 CRY2 Circadian clock gene variant affecting fasting glucose, hepatic lipid metabolism, and seasonal metabolic responses CRY2 Sleep & Circadian Rhythm —
rs12696304 TERC Regulatory variant near the telomerase RNA gene associated with shorter telomeres and accelerated cellular aging TERC Neuroinflammation & Oxidative Stress —
rs1611115 DBH Strongest known genetic determinant of dopamine beta-hydroxylase activity, controlling the dopamine-to-norepinephrine ratio DBH Neurotransmitter Metabolism —
rs11136000 CLU Intronic variant in clusterin gene affecting Alzheimer's disease risk through regulation of amyloid-beta clearance CLU Cognitive Health & Neurodegeneration —
rs12086634 HSD11B1 Modulates local cortisol activation from cortisone in liver and adipose tissue, influencing visceral fat, insulin sensitivity, and metabolic syndrome risk HSD11B1 Anxiety & Stress Response, Neuroendocrine & Hormonal Mood —
rs16147 NPY Promoter variant in neuropeptide Y that modulates NPY expression under stress, affecting stress resilience, anxiety vulnerability, appetite regulation, and migraine susceptibility NPY Mood & Depression, Anxiety & Stress Response —
rs1801198 TCN2 Transcobalamin II variant affecting cellular delivery of vitamin B12 via holotranscobalamin binding efficiency TCN2 Methylation & Brain Nutrients —
rs10741657 CYP2R1 Vitamin D activation — converts D3 to 25(OH)D in the liver CYP2R1 Methylation & Brain Nutrients —
rs12248560 CYP2C19 Increased function CYP2C19 variant - rapid/ultrarapid metabolizer CYP2C19 Psychiatric Pharmacogenomics —
rs16944 IL1B Promoter variant affecting IL-1 beta production, influencing inflammatory response and cardiovascular disease risk IL1B Neuroinflammation & Oxidative Stress —
rs16969968 CHRNA5 Nicotinic receptor variant strongly associated with heavy smoking, nicotine dependence, and increased lung cancer risk CHRNA5 Addiction & Reward Processing —
rs1800497 DRD2/ANKK1 Reduces dopamine D2 receptor density in the striatum, affecting reward processing, reinforcement learning, and addiction susceptibility DRD2/ANKK1 Neurotransmitter Metabolism, Addiction & Reward Processing —
rs1841499 NEGR1 Hypothalamic appetite regulator variant linking obesity susceptibility to migraine risk via shared neural pathways NEGR1 Mood & Depression —
rs1800883 HTR5A Promoter/5' UTR variant in the serotonin 5-HT5A receptor gene affecting receptor expression, linked to schizophrenia susceptibility and executive function HTR5A Mood & Depression, Neurotransmitter Metabolism —
rs1800955 DRD4 Promoter variant that modulates dopamine D4 receptor expression in the prefrontal cortex, influencing novelty seeking and cognitive flexibility DRD4 Neurotransmitter Metabolism, Addiction & Reward Processing —
rs11558538 HNMT HNMT structural variant - reduces enzyme stability and histamine clearance in tissues HNMT Neurotransmitter Metabolism —
rs2815752 NEGR1 Top obesity GWAS variant near NEGR1 — affects hypothalamic appetite regulation and neuronal growth NEGR1 Mood & Depression —
rs16947 CYP2D6 Common CYP2D6 variant defining the *2 allele; previously considered normal-function but recent evidence shows reduced expression through altered splicing CYP2D6 Psychiatric Pharmacogenomics —
rs1800872 IL10 Promoter variant affecting IL-10 production — a key anti-inflammatory cytokine regulating inflammation and cardiovascular risk IL10 Neuroinflammation & Oxidative Stress —
rs2271933 HCRTR1 Missense variant in the orexin/hypocretin receptor 1 that alters G-protein signaling, increasing susceptibility to migraine, panic disorder, mood dysregulation, and heightened arousal responses HCRTR1 Anxiety & Stress Response —
rs1799941 SHBG Promoter region variant affecting sex hormone-binding globulin levels, with the A allele increasing SHBG by 15-25% and influencing free testosterone and estradiol bioavailability SHBG Neuroendocrine & Hormonal Mood —
rs1800795 IL6 Promoter variant controlling interleukin-6 expression — affects inflammation, exercise recovery, and cardiovascular risk IL6 Neuroinflammation & Oxidative Stress —
rs1799971 OPRM1 Mu-opioid receptor variant affecting opioid response, pain sensitivity, and potentially naltrexone efficacy OPRM1 Addiction & Reward Processing —
rs25531 SLC6A4 Promoter SNP near 5-HTTLPR that modifies serotonin transporter expression and antidepressant response SLC6A4 Mood & Depression, Psychiatric Pharmacogenomics, Neurotransmitter Metabolism —
rs1801260 CLOCK Core circadian clock transcription factor variant affecting mRNA stability, associated with evening preference, delayed sleep onset, and shorter sleep duration CLOCK Sleep & Circadian Rhythm —
rs1544410 VDR Vitamin D receptor — affects how well vitamin D activates cellular processes VDR Methylation & Brain Nutrients —
rs279858 GABRA2 GABA-A receptor alpha-2 subunit variant affecting alcohol response, anxiety, and addiction vulnerability GABRA2 Anxiety & Stress Response, Addiction & Reward Processing —
rs324420 FAAH Affects anandamide levels through altered FAAH enzyme stability, influencing pain sensitivity, stress response, fear extinction, and mood regulation FAAH Anxiety & Stress Response, Addiction & Reward Processing —
rs1991517 TSHR Affects TSH receptor sensitivity and thyroid hormone regulation; influences TSH levels, metabolic function, and congenital hypothyroidism risk TSHR Neuroendocrine & Hormonal Mood —
rs17070145 WWC1 Influences episodic memory performance and hippocampal function through the KIBRA protein's role in synaptic plasticity WWC1 Cognitive Health & Neurodegeneration —
rs41423247 NR3C1 Intronic glucocorticoid receptor variant affecting cortisol sensitivity and stress response regulation NR3C1 Mood & Depression, Anxiety & Stress Response —
rs4570625 TPH2 Promoter variant affecting brain serotonin synthesis enzyme; influences emotional reactivity, anxiety, and depression risk TPH2 Mood & Depression, Neurotransmitter Metabolism —
rs17649553 MAPT Haplotype-tagging variant distinguishing MAPT H1 and H2 clades, affecting risk for Parkinson disease, progressive supranuclear palsy, and other tauopathies MAPT Cognitive Health & Neurodegeneration —
rs2736100 TERT Common intron 2 variant in the telomerase gene that influences telomere length, with the C allele associated with longer telomeres and increased cancer risk, while the A allele links to shorter telomeres and higher risk of degenerative diseases TERT Neuroinflammation & Oxidative Stress —
rs2234693 ESR1 Estrogen receptor alpha intron variant affecting receptor expression and estrogen sensitivity ESR1 Neuroendocrine & Hormonal Mood —
rs53576 OXTR Most-studied oxytocin receptor variant, influencing empathy, social sensitivity, stress resilience through social buffering, and emotional regulation OXTR Mood & Depression, Anxiety & Stress Response —
rs225014 DIO2 Affects conversion of inactive T4 to active T3 thyroid hormone in brain, pituitary, and peripheral tissues DIO2 Neuroendocrine & Hormonal Mood —
rs429358 APOE Lipid metabolism and Alzheimer's risk - E4 carriers respond worse to high saturated fat APOE Cognitive Health & Neurodegeneration —
rs1801131 MTHFR Second MTHFR variant affecting enzyme activity in the regulatory domain MTHFR Methylation & Brain Nutrients —
rs2802292 FOXO3 Longevity-associated intronic enhancer variant with 1.9-fold increased probability of reaching age 95 FOXO3 Cognitive Health & Neurodegeneration —
rs1801133 MTHFR Key enzyme for converting folate to its active methylfolate form MTHFR Methylation & Brain Nutrients —
rs228697 PER3 Core clock gene variant that shifts circadian period length and influences morning vs evening chronotype PER3 Sleep & Circadian Rhythm —
rs2287161 CRY1 Cryptochrome 1 circadian gene variant influencing glucose metabolism, sleep timing, mood regulation, and metabolic responses to diet CRY1 Sleep & Circadian Rhythm —
rs601338 FUT2 Determines secretor status — whether ABO blood group antigens are secreted into bodily fluids, affecting gut microbiome, vitamin B12 levels, and infection susceptibility FUT2 Methylation & Brain Nutrients —
rs6311 HTR2A Regulatory variant in serotonin 2A receptor gene affecting SSRI side effects and potentially treatment response HTR2A Mood & Depression, Psychiatric Pharmacogenomics, Neurotransmitter Metabolism —
rs6323 MAOA X-linked monoamine oxidase A variant affecting enzyme activity and neurotransmitter breakdown MAOA Mood & Depression, Neurotransmitter Metabolism, Addiction & Reward Processing —
rs1801394 MTRR B12 recycling enzyme — regenerates active B12 for the methylation cycle MTRR Methylation & Brain Nutrients —
rs2304672 PER2 Regulatory variant in a core clock gene that influences circadian timing, sleep-wake preference, and reward processing PER2 Sleep & Circadian Rhythm —
rs1805087 MTR Methionine synthase — uses B12 to convert homocysteine to methionine MTR Methylation & Brain Nutrients —
rs324981 NPSR1 Gain-of-function missense variant in the neuropeptide S receptor that increases receptor signaling ~10-fold, promoting wakefulness and reducing sleep duration NPSR1 Sleep & Circadian Rhythm —
rs7412 APOE APOE E2 variant - generally protective for cardiovascular health APOE Cognitive Health & Neurodegeneration —
rs28371725 CYP2D6 Intronic splice variant causing decreased CYP2D6 enzyme activity through aberrant splicing CYP2D6 Psychiatric Pharmacogenomics —
rs35333999 PER2 Missense variant in core circadian clock gene PER2 that lengthens intrinsic circadian period and shifts chronotype toward eveningness PER2 Sleep & Circadian Rhythm —
rs2236225 MTHFD1 Folate processing enzyme — reduced stability increases choline need MTHFD1 Methylation & Brain Nutrients —
rs234706 CBS Common synonymous variant in the CBS gene associated with reduced cardiovascular disease risk and enhanced response to folate supplementation CBS Methylation & Brain Nutrients —
rs4446909 ASMT Final enzyme in melatonin synthesis; promoter variant reduces ASMT expression and lowers melatonin production, affecting sleep onset and circadian rhythm ASMT Sleep & Circadian Rhythm —
rs3745274 CYP2B6 Decreased-function variant affecting metabolism of efavirenz, methadone, bupropion, and cyclophosphamide CYP2B6 Psychiatric Pharmacogenomics —
rs9536314 KLOTHO Longevity-associated variant exhibiting overdominance where heterozygotes show enhanced cognition and lifespan while homozygotes have reduced survival KLOTHO Cognitive Health & Neurodegeneration —
rs356182 SNCA Parkinson's disease GWAS risk variant affecting alpha-synuclein expression and neuronal differentiation SNCA Cognitive Health & Neurodegeneration —
rs5443 GNB3 Synonymous exon-10 variant that triggers alternative splicing of the G-protein beta-3 subunit, amplifying signaling through virtually every GPCR — affecting blood pressure, weight regulation, hormonal responses, sleep timing, and antidepressant efficacy GNB3 Psychiatric Pharmacogenomics —
rs3892097 CYP2D6 CYP2D6 *4 splice-defect null allele — the most common loss-of-function CYP2D6 variant in Europeans (~20% allele frequency) and the most-prescribed-against PGx variant worldwide. Determines codeine and tramadol failure (no morphine/O-desmethyltramadol conversion), reduced tamoxifen→endoxifen activation, and elevated exposure to many SSRIs and tricyclic antidepressants metabolized by CYP2D6. CYP2D6 Psychiatric Pharmacogenomics —
rs3751143 P2RX7 Loss-of-function variant in the P2X7 receptor that reduces inflammatory response and may modulate pain sensitivity P2RX7 Neuroinflammation & Oxidative Stress —
rs5751876 ADORA2A Adenosine A2A receptor variant that determines individual sensitivity to caffeine's effects on anxiety and sleep ADORA2A Sleep & Circadian Rhythm —
rs4680 COMT Dopamine/catecholamine breakdown — affects stress response and methyl donor tolerance COMT Anxiety & Stress Response, Neurotransmitter Metabolism, Methylation & Brain Nutrients —
rs3851179 PICALM Variant in the PICALM gene affecting amyloid-beta clearance across the blood-brain barrier and Alzheimer's disease risk PICALM Cognitive Health & Neurodegeneration —
rs4244285 CYP2C19 No-function CYP2C19 variant affecting PPIs, clopidogrel, and some antidepressants CYP2C19 Psychiatric Pharmacogenomics —
rs4880 SOD2 Primary mitochondrial antioxidant enzyme - variant reduces superoxide detoxification in mitochondria SOD2 Neuroinflammation & Oxidative Stress —
rs743572 CYP17A1 Promoter variant affecting 17α-hydroxylase expression and steroid hormone synthesis, influencing cortisol, DHEA, androgen, and estrogen production CYP17A1 Neuroendocrine & Hormonal Mood —
rs5030655 CYP2D6 Frameshift deletion causing no enzyme function, defining poor metabolizer status for many drugs including codeine, tramadol, and antidepressants CYP2D6 Psychiatric Pharmacogenomics —
rs7946 PEMT Phosphatidylcholine production — affects dietary choline requirements PEMT Methylation & Brain Nutrients —
rs965513 FOXE1 Strongest GWAS thyroid locus — regulatory variant near FOXE1 affecting thyroid development, TSH levels, and differentiated thyroid cancer risk FOXE1 Neuroendocrine & Hormonal Mood —
rs6265 BDNF Key neurotrophin variant that controls activity-dependent BDNF release, affecting memory consolidation, neuroplasticity, and stress resilience BDNF Mood & Depression —
rs671 ALDH2 Alcohol metabolism - flush reaction and cancer risk ALDH2 Addiction & Reward Processing —
rs762551 CYP1A2 CYP1A2 *1F intronic inducibility variant — defines fast vs slow caffeine metabolizer status and affects clearance of clozapine, theophylline, and tizanidine. The slow-metabolizer C allele blunts the smoking-induced enzyme upregulation that normally accelerates these drugs in heavy smokers. CYP1A2 Sleep & Circadian Rhythm —
rs744373 BIN1 Second strongest genetic risk factor for Alzheimer's disease after APOE, associated with increased tau pathology and accelerated cognitive decline BIN1 Cognitive Health & Neurodegeneration —
rs75932628 TREM2 Rare missense variant in microglial receptor TREM2 that significantly increases late-onset Alzheimer's disease risk through impaired microglial function and amyloid clearance TREM2 Cognitive Health & Neurodegeneration —
rs76904798 LRRK2 Common noncoding variant upstream of LRRK2 that increases gene expression in microglia and Parkinson's disease risk LRRK2 Cognitive Health & Neurodegeneration —
90 variants