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Genetic Variants

Variant Gene Category Result
rs1800497 DRD2/ANKK1 Reduces dopamine D2 receptor density in the striatum, affecting reward processing, reinforcement learning, and addiction susceptibility DRD2/ANKK1 Neurotransmitter Metabolism, Addiction & Reward Processing —
rs1801133 MTHFR Key enzyme for converting folate to its active methylfolate form MTHFR Methylation & Brain Nutrients —
rs225014 DIO2 Affects conversion of inactive T4 to active T3 thyroid hormone in brain, pituitary, and peripheral tissues DIO2 Neuroendocrine & Hormonal Mood —
rs2802292 FOXO3 Longevity-associated intronic enhancer variant with 1.9-fold increased probability of reaching age 95 FOXO3 Cognitive Health & Neurodegeneration —
rs3892097 CYP2D6 Major enzyme for metabolizing ~25% of medications including opioids, antidepressants, and beta-blockers CYP2D6 Psychiatric Pharmacogenomics —
rs429358 APOE Lipid metabolism and Alzheimer's risk - E4 carriers respond worse to high saturated fat APOE Cognitive Health & Neurodegeneration —
rs6265 BDNF Key neurotrophin variant that controls activity-dependent BDNF release, affecting memory consolidation, neuroplasticity, and stress resilience BDNF Mood & Depression —
rs1065852 CYP2D6 Decreased function CYP2D6 variant common in Asian populations CYP2D6 Psychiatric Pharmacogenomics —
rs11206244 DIO1 Common variant in the 3' UTR of the DIO1 gene affecting thyroid hormone metabolism and T3/T4 ratio DIO1 Neuroendocrine & Hormonal Mood —
rs17070145 WWC1 Influences episodic memory performance and hippocampal function through the KIBRA protein's role in synaptic plasticity WWC1 Cognitive Health & Neurodegeneration —
rs1800955 DRD4 Promoter variant that modulates dopamine D4 receptor expression in the prefrontal cortex, influencing novelty seeking and cognitive flexibility DRD4 Neurotransmitter Metabolism, Addiction & Reward Processing —
rs1801131 MTHFR Second MTHFR variant affecting enzyme activity in the regulatory domain MTHFR Methylation & Brain Nutrients —
rs7412 APOE APOE E2 variant - generally protective for cardiovascular health APOE Cognitive Health & Neurodegeneration —
rs9536314 KLOTHO Longevity-associated variant exhibiting overdominance where heterozygotes show enhanced cognition and lifespan while homozygotes have reduced survival KLOTHO Cognitive Health & Neurodegeneration —
rs1051266 SLC19A1 Folate transporter — how well folate gets into your cells SLC19A1 Methylation & Brain Nutrients —
rs1611115 DBH Strongest known genetic determinant of dopamine beta-hydroxylase activity, controlling the dopamine-to-norepinephrine ratio DBH Neurotransmitter Metabolism —
rs1799941 SHBG Promoter region variant affecting sex hormone-binding globulin levels, with the A allele increasing SHBG by 15-25% and influencing free testosterone and estradiol bioavailability SHBG Neuroendocrine & Hormonal Mood —
rs2736100 TERT Common intron 2 variant in the telomerase gene that influences telomere length, with the C allele associated with longer telomeres and increased cancer risk, while the A allele links to shorter telomeres and higher risk of degenerative diseases TERT Neuroinflammation & Oxidative Stress —
rs4244285 CYP2C19 No-function CYP2C19 variant affecting PPIs, clopidogrel, and some antidepressants CYP2C19 Psychiatric Pharmacogenomics —
rs12248560 CYP2C19 Increased function CYP2C19 variant - rapid/ultrarapid metabolizer CYP2C19 Psychiatric Pharmacogenomics —
rs12696304 TERC Regulatory variant near the telomerase RNA gene associated with shorter telomeres and accelerated cellular aging TERC Neuroinflammation & Oxidative Stress —
rs2236225 MTHFD1 Folate processing enzyme — reduced stability increases choline need MTHFD1 Methylation & Brain Nutrients —
rs4570625 TPH2 Promoter variant affecting brain serotonin synthesis enzyme; influences emotional reactivity, anxiety, and depression risk TPH2 Mood & Depression, Neurotransmitter Metabolism —
rs744373 BIN1 Second strongest genetic risk factor for Alzheimer's disease after APOE, associated with increased tau pathology and accelerated cognitive decline BIN1 Cognitive Health & Neurodegeneration —
rs11136000 CLU Intronic variant in clusterin gene affecting Alzheimer's disease risk through regulation of amyloid-beta clearance CLU Cognitive Health & Neurodegeneration —
rs1801394 MTRR B12 recycling enzyme — regenerates active B12 for the methylation cycle MTRR Methylation & Brain Nutrients —
rs6311 HTR2A Regulatory variant in serotonin 2A receptor gene affecting SSRI side effects and potentially treatment response HTR2A Mood & Depression, Psychiatric Pharmacogenomics, Neurotransmitter Metabolism —
rs1805087 MTR Methionine synthase — uses B12 to convert homocysteine to methionine MTR Methylation & Brain Nutrients —
rs25531 SLC6A4 Promoter SNP near 5-HTTLPR that modifies serotonin transporter expression and antidepressant response SLC6A4 Mood & Depression, Psychiatric Pharmacogenomics, Neurotransmitter Metabolism —
rs743572 CYP17A1 Promoter variant affecting 17α-hydroxylase expression and steroid hormone synthesis, influencing cortisol, DHEA, androgen, and estrogen production CYP17A1 Neuroendocrine & Hormonal Mood —
rs75932628 TREM2 Rare missense variant in microglial receptor TREM2 that significantly increases late-onset Alzheimer's disease risk through impaired microglial function and amyloid clearance TREM2 Cognitive Health & Neurodegeneration —
rs1544410 VDR Vitamin D receptor — affects how well vitamin D activates cellular processes VDR Methylation & Brain Nutrients —
rs1800883 HTR5A Promoter/5' UTR variant in the serotonin 5-HT5A receptor gene affecting receptor expression, linked to schizophrenia susceptibility and executive function HTR5A Mood & Depression, Neurotransmitter Metabolism —
rs2234693 ESR1 Estrogen receptor alpha intron variant affecting receptor expression and estrogen sensitivity ESR1 Neuroendocrine & Hormonal Mood —
rs3851179 PICALM Variant in the PICALM gene affecting amyloid-beta clearance across the blood-brain barrier and Alzheimer's disease risk PICALM Cognitive Health & Neurodegeneration —
rs762551 CYP1A2 Caffeine metabolism - affects how quickly you process caffeine CYP1A2 Sleep & Circadian Rhythm —
rs10741657 CYP2R1 Vitamin D activation — converts D3 to 25(OH)D in the liver CYP2R1 Methylation & Brain Nutrients —
rs1205 CRP 3' UTR variant that modulates baseline C-reactive protein levels and inflammatory status CRP Neuroinflammation & Oxidative Stress —
rs1800795 IL6 Promoter variant controlling interleukin-6 expression — affects inflammation, exercise recovery, and cardiovascular risk IL6 Neuroinflammation & Oxidative Stress —
rs1801260 CLOCK Core circadian clock transcription factor variant affecting mRNA stability, associated with evening preference, delayed sleep onset, and shorter sleep duration CLOCK Sleep & Circadian Rhythm —
rs356182 SNCA Parkinson's disease GWAS risk variant affecting alpha-synuclein expression and neuronal differentiation SNCA Cognitive Health & Neurodegeneration —
rs6323 MAOA X-linked monoamine oxidase A variant affecting enzyme activity and neurotransmitter breakdown MAOA Mood & Depression, Neurotransmitter Metabolism, Addiction & Reward Processing —
rs1360780 FKBP5 Co-chaperone of the glucocorticoid receptor that regulates cortisol feedback — the T allele impairs stress recovery and, combined with early adversity, strongly increases risk of PTSD and depression FKBP5 Anxiety & Stress Response —
rs16944 IL1B Promoter variant affecting IL-1 beta production, influencing inflammatory response and cardiovascular disease risk IL1B Neuroinflammation & Oxidative Stress —
rs228697 PER3 Core clock gene variant that shifts circadian period length and influences morning vs evening chronotype PER3 Sleep & Circadian Rhythm —
rs7946 PEMT Phosphatidylcholine production — affects dietary choline requirements PEMT Methylation & Brain Nutrients —
rs2304672 PER2 Regulatory variant in a core clock gene that influences circadian timing, sleep-wake preference, and reward processing PER2 Sleep & Circadian Rhythm —
rs4680 COMT Dopamine/catecholamine breakdown — affects stress response and methyl donor tolerance COMT Anxiety & Stress Response, Neurotransmitter Metabolism, Methylation & Brain Nutrients —
rs53576 OXTR Most-studied oxytocin receptor variant, influencing empathy, social sensitivity, stress resilience through social buffering, and emotional regulation OXTR Mood & Depression, Anxiety & Stress Response —
rs10830963 MTNR1B Melatonin receptor variant that extends nighttime melatonin signaling in pancreatic beta cells, impairing glucose-stimulated insulin secretion — especially when meals are eaten late MTNR1B Sleep & Circadian Rhythm —
rs234706 CBS Common synonymous variant in the CBS gene associated with reduced cardiovascular disease risk and enhanced response to folate supplementation CBS Methylation & Brain Nutrients —
51 variants